Process for preparing polypeptide

Details Process for preparing polypeptide Process for preparing polypeptide

1997-07-18

1999-04-06

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

530351, 530350, 530412, C12P 2100, C07K 1452

Patent

active

058916636

ABSTRACT:
A method for converting a precursor of a polypeptide that induces IFN-.gamma. production in immunocompetent cells, characterized in that it comprises a step of contacting an interleukin-1.beta. converting enzyme with the precursor to convert it into an active polypeptide that induces IFN-.gamma. production in immunocompetent cells.

REFERENCES:
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Miller, Douglas, et al., "Purification and characterization of active human interleukin-1beta converting enzyme from THP.1 monocytic cells.", J. Biological Chemistry, vol. 268, No. 24, pp. 18062-18069 (1993).
Kuroki, Toshio et al., Jikken-Igaku-Bessatsu-Saibo-Kogaku-Handbook, (1992).
Yokota, Takashi ed. et al., Jikken-Igaku-Bessatsu-Biomaterial Series 3, "Genetic Cloning Experimental Method" (1993).
Laemmli, U.K., "Cleavage of structural proteins during the assembly of the head of bacteriophage T4.", Nature, vol. 227, pp. 680-685 (1970).
Hay, Robert ed. et al., "Catalogue of cell lines & hybridomas.", 6th Ed. (1988).
Alnemri, Emad, et al., "Cloning and expression of four novel isoforms of human interleukin-1beta converting enzyme with different apoptotic activities.", J. Biol. Chemistry, vol. 270, No. 9, pp. 4312-4317 (1995).

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