Polypeptides of human copper/zinc superoxide dimutase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

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43525233, C12N 902, C12N 1503

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050665910

ABSTRACT:
Methods and compositions are provided for the production of human copper/zinc superoxide dimutase (SOD) polypeptides in microorganisms. Bacterially produced human CuZn SOD polypeptides are provided.
E. coli strain D1210 (pSODX8) was deposited at the A.T.C.C. on Sept. 27, 1983 and given Accession No. 39453. Yeast strain 2150-2-3 (pCl/1GAPSOD) and E. coli strains D1210 (pSOD11) and D1210 (pS2OR) were deposited at the A.T.C.C. on May 9, 1984, and were given Accession Nos. 20708, 39679 and 39680, respectively.

REFERENCES:
Barra et al; FEBS Lett. 102: 53 (1980).
Jabusch et al; Biochemistry 19: 2310 (1980).
Steinman et al., J. Biol. Chem. 249:7326-7338 (1974).
Lieman-Hurwitz et al., Proc. Natl. Acad. Sci. U.S.A., 79:2808-2811 (1982).
Marklund, Proc. Natl. Acad. Sci. U.S.A. 79:7634-7638 (1982).
Sherman et al., Proc. Natl. Acad. Sci. U.S.A. 80:5465-5469 (1983).

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