Fractionation of polyalkylene oxide-conjugated hemoglobin soluti

Details Fractionation of polyalkylene oxide-conjugated hemoglobin soluti Fractionation of polyalkylene oxide-conjugated hemoglobin soluti

1993-11-03

1995-12-26

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530385, A61K 3816, C07K 1708, C12N 1108

Patent

active

054788056

ABSTRACT:
Hemoglobin-containing solutions containing polyalkyene oxide-conjugated hemoglobin having a molecular weight greater than about 85,000 daltons and a degree of substitution of at least five polyalkylene oxide conjugates per hemoglobin molecule are described that are not associated with hemoglobinuria in mammals. A method of simultaneously fractionating and purifying polyalkylene oxide-conjugated hemoglobins is also disclosed.

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