Metallacarborane chelates

Details Metallacarborane chelates Metallacarborane chelates

1988-05-31

1991-11-19

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 8591, 424 9, 530389, 530390, 530391, A61K 4902, A61K 3944, C07K 1706

Patent

active

050664794

ABSTRACT:
Metallacarborane chelate-antibody compounds which are useful for radioimmunodetection and radiotherapy. The compounds have the formula ##STR1## wherein X is a metal or radioisotope of said metal, Y is a rotation resistant organic chelate bridge moiety, Z is an antibody linkage moiety and AB is an antibody. Metallacarborane chelate and carborane chelate compounds are also disclosed which are useful in preparing the final metallacarborane chelate-antibody compound which is used for radioimmunodetection and radiotherapy.

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J. N. Francis, C. J. Jones, and M. F. Hawthorne, (1972), "Chemistry of Bis(7,8-Dicarbollyl)Metalates". Reaction between [(-7,8-B.sub.9 C.sub.2 H.sub.11).sub.2 Co]-- and Aryl Diazonium Salts brochure, [reprinted from Journal of the American Chem. Soc., 94, 4878 (1972).]
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