Method for reducing or preventing post-surgical adhesion formati

Details Method for reducing or preventing post-surgical adhesion formati Method for reducing or preventing post-surgical adhesion formati

1995-06-07

1999-04-06

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424423, A61K 970

Patent

active

058914609

ABSTRACT:
Compositions and methods for minimizing or preventing post-surgical adhesion formation between tissue, e.g., organ, surfaces in body cavities, whereby an effective therapeutic amount of anti-asthmatic ketotifen (9H)-one, hydrogen fumarate salt) thereof is administered to the target injury site for a period of time sufficient to permit tissue repair. Ketotifen or analogs thereof is preferably administered in conjunction with a delivery vehicle (e.g., microcapsules, microspheres, biodegradable polymer films, lipid-based delivery systems such as liposomes and lipid foams, crystalloid and viscous instillates and absorbable mechanical barriers) useful for maintaining local concentrations of the inhibitor at the injury site at an effective level for a sustained period of time.

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