Long range surface plasma resonance immunoassay

Details Long range surface plasma resonance immunoassay Long range surface plasma resonance immunoassay

1994-02-17

1995-12-26

Saunders, David A.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

356317, 356318, 356445, 422 57, 422 8205, 422 8208, 422 8211, 435808, 436164, 436165, 436172, 436525, 436527, 436805, G01N 33543, G01N 33553

Patent

active

054787556

ABSTRACT:
A method of assaying for a ligand in a sample involves incubating the sample in contact with a specific binding partner for the ligand carried on one surface of an optical structure, irradiating the structure at a suitable angle or range of angles to the normal such that the resonance and/or total internal reflection of the radiation occurs within the optical structure and/or the layer of specific binding partner, and analyzing the radiation in order to determine whether, and if desired the extent to which and/or rate at which the generated radiation and/or optical characteristics of the optical structure are altered by complex formation.

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Quail et al, "Long Range Surface Plasmon Modes in Silver & Aluminum Films", Optics Letters, vol. 8, No. 7, 1983, pp. 377-379.
Brenner et al, "Angular Emission Profiles of Dye Molecules Excited by Surface Plasmon Waves at a Metal Surface", Optics Communications vol. 30 (2), 1979, pp. 145-149.

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