Process for the preparation of 2-aminophenyl thioethers

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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564413, 564440, 560 17, C07C 85145, C07C 8524

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active

048087521

ABSTRACT:
A process for the preparation of 2-aminophenyl thioethers of the formula (1) ##STR1## in which R represents an alkylC.sub.1 -C.sub.6 group which can be substituted by hydroxyl, alkoxyC.sub.1 -C.sub.4, carboxyl, --COO-alkyl-C.sub.1 -C.sub.4, alkenylC.sub.2 -C.sub.6 or phenyl groups or by the radical ##STR2## and X and Y are each a hydrogen or halogen atom or an alkylC.sub.1 -C.sub.6, alkoxyC.sub.1 -C.sub.6 or nitro group, wherein the salts of the formula (4) ##STR3## in which X and Y have the stated meanings and Me denotes an alkali metal atom or the equivalent amount of an alkaline earth metal atom, which are obtainable in a known manner by reacting 2-aminobenzothiazoles of the formula (3) ##STR4## in which X and Y have the stated meanings, with an alkali metal or alkaline earth metal hydroxides in an alkali-stable anhydrous or virtually anhydrous solvent are reacted, in the isolated form or, advantageously in suspension in the mixture obtained in the ring-opening step, with an alkylating agent of the formula (2)

REFERENCES:
patent: 2034459 (1935-03-01), Cole
patent: 3102142 (1963-08-01), Horwitz et al.
patent: 3920617 (1975-11-01), Hirosawa et al.
patent: 4370483 (1983-01-01), Papenfuhs
Smith, P. A. S., The Chemistry of Open-Chain Organic Nitrogen Compounds, vol. I (1965) p. 270.

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