Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1986-12-19
1989-02-28
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530390, 530808, 530370, 424 8591, 514 2, 514885, 514 8, C07K 1500, A61K 39395
Patent
active
048087050
ABSTRACT:
Highly stable pharmaceutical compositions suitable for parenteral administration to animals or humans comprising a therapeutically effective amount of an RTA-immunoconjugate dissolved in an inert carrier method comprising a stabilizer are claimed. Screening methods for selecting stabilizers effective in preventing precipitation and aggregation of such compositions are described. Preferred stabilizers includes glycerol at a concentration (v/v) of from about 25 to about 35%; dextran sulfates having molecular weights from about 0.1.times.10.sup.6 to about 2.times.10.sup.6 daltons; and human serum albumin.
The invention further comprises such compositions which have been lyophilized and/or reconstituted wherein the stabilizer is non-volatile, and may further comprise a carbohydrate stabilizer.
The invention further comprises stabilized RTA compositions.
REFERENCES:
patent: 4439181 (1984-03-01), Blackshear et al.
patent: 4507234 (1985-03-01), Kato et al.
patent: 4623717 (1986-11-01), Fernandes et al.
Jansen et al., Immunological Rev., vol. 62, 1982, pp. 185-216.
Cetus Corporation
Draper Garnette D.
Giotta Gregory J.
Halluin Albert P.
Lauder Leona L.
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