Stimulation of cytokine production

Details Stimulation of cytokine production Stimulation of cytokine production

1993-09-29

1995-12-26

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424 851, 424 852, 424443, A61F 1300

Patent

active

054785669

ABSTRACT:
3.beta.,7.beta.,17.beta.-androstenetriol (".beta.AET") may be used to increase production of IL-2 in cell culture and in the intact animal. Increase in IL-2 under stimulating effect of .beta.AET provides benefits associated with IL-2 administration without the untoward effects such as increased cortisol production.

REFERENCES:
patent: 4978532 (1990-12-01), El-Rashidy
patent: 5077284 (1991-12-01), Loria
patent: 5206008 (1993-04-01), Loria
patent: 5277907 (1994-01-01), Loria
Daynes, R. A. et al Eur. J. Immunol., 1990 vol. 20, pp. 793-802.
Meikle, A. W. et al J. Steroid Biochem Molec Biol., 1992, vol. 42, pp. 293-304.
Suzuki, T. et al. Clin. Immunol and Immuno-pathology, 61, pp. 202-211, 1991.

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