Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-06-02
1989-02-28
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514314, 514381, 514382, 514432, 514456, 546165, 546166, 548251, 549 23, 549398, A61K 3135, A61K 3138, A61K 3147
Patent
active
048085979
ABSTRACT:
Certain carboxylic acids of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, and certain esters and amides thereof, are useful for inhibiting the degradation of articular cartilage when administered to a mammalian subject afflicted with an arthritic disease. X is O, S, SO, SO.sub.2, NH, NCH.sub.3 or NCOCH.sub.3 ; and n is zero or one.
REFERENCES:
Loeliger et al., Eur. J. Med. Chem., vol. 15, pp. 9-15 (1980).
Hoffman William W.
Kraska Allen R.
Lumb J. Trevor
Pfizer Inc.
Raymond Richard L.
Richardson Peter C.
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