Method for inhibiting the degradation of cartilage

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514314, 514381, 514382, 514432, 514456, 546165, 546166, 548251, 549 23, 549398, A61K 3135, A61K 3138, A61K 3147

Patent

active

048085979

ABSTRACT:
Certain carboxylic acids of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, and certain esters and amides thereof, are useful for inhibiting the degradation of articular cartilage when administered to a mammalian subject afflicted with an arthritic disease. X is O, S, SO, SO.sub.2, NH, NCH.sub.3 or NCOCH.sub.3 ; and n is zero or one.

REFERENCES:
Loeliger et al., Eur. J. Med. Chem., vol. 15, pp. 9-15 (1980).

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