Process for preparing alkyl-L-alanyl-L-proline derivatives

Details Process for preparing alkyl-L-alanyl-L-proline derivatives Process for preparing alkyl-L-alanyl-L-proline derivatives

1993-09-16

1994-10-25

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548227, C07D20712

Patent

active

053590864

ABSTRACT:
A process for preparing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxy anhydride from N-[1(S)-ethoxycarbonyl-3 -phenylpropyl]-L-alanine and N,N'-carbonyldiimidazole and the condensation thereof with L-proline silyl ester hydrochloride. The condensation product is used as an angiotensin converting enzyme (ACE) inhibitor.

REFERENCES:
patent: 4925969 (1990-05-01), Takahashi et al.
patent: 5136044 (1992-08-01), Inoue et al.
patent: 5227497 (1993-07-01), Inoue et al.
Japanese Article (6 pp.) titled: "A New Method for Synthesizing .alpha.-Amino Acid N-Carboxy Anydride (NCA)".
English article (5 pp.) about "Synthetic Polypeptides" pp. 3213-3217.

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