Process for synthesizing N-[(1'-allyl-2'pyrrolidinyl) methyl]2-m

Details Process for synthesizing N-[(1'-allyl-2'pyrrolidinyl) methyl]2-m Process for synthesizing N-[(1'-allyl-2'pyrrolidinyl) methyl]2-m

1985-12-18

1989-02-14

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548261, 548567, 562437, 562458, 564183, A61K 3141, C07D24918

Patent

active

048047651

ABSTRACT:
The invention concerns a novel process for the synthesis of N-[(1'-allyl-2'-pyrrolidinyl) methyl]-2-methoxy-4,5-azimidobenzamide, which successively comprises the preparation of 2-methoxy-4,5-diaminobenzoic acid, 2-methoxy-4,5-diacetylaminobenzoic acid, N-(2',5'-dihalopentyl)-2-methoxy-4,5-diacetylaminobenzamide, N-[(1'-allyl-2'-pyrrolidinyl) methyl]-2-methoxy-4,5-diacetylaminobenzamide and then N-[(1'-allyl-2'-pyrrolidinyl) methyl]-2-methoxy-4,5-azimido benzamide.

REFERENCES:
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patent: 4673686 (1987-06-01), Thominet
Albertson, from Organic Reactions, v. 12 (John Wiley and Sons, N.Y.) 1962, pp. 162-165 and 189-196.
Carey and Sundberg, Advanced Organic Chemistry, Part B (1977) (Plenum Press, N.Y.), p. 476.
March, Advanced Organic Chemistry, 2nd ed. (1977) (McGraw Hill Book Co. N.Y.) p. 383.
Balcom, D., J. Am. Chem. Soc. (1953), v. 75, 4334.
Pollack, R. M., J. Am. Chem. Soc. (1970) v. 92, 7190-7194.

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