Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-12-24
1989-02-14
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 16, C07D47110, A61K 31395
Patent
active
048046655
ABSTRACT:
Azaspiro compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, a hydrocarbon residue which may have a substituent, or an acyl group which may have a substituent; R.sub.3 represents hydrogen or a hydrocarbon residue which may have a substituent; each of X.sub.1 and X.sub.2 is oxygen or sulfur; Y represents oxygen, sulfur or a group of the formula: --N(R.sub.4)--, wherein R.sub.4 represents hydrogen or a lower alkyl group; m represents 0 or 1; n represents 0 or 1, and its salt are novel compounds, possess excellent brain function-improving action, and are of use as drugs for the prevention and therapy of senile dementia of Alzheimer type, vascular-type dementia and dementia derived from Alzheimer's disease, Pick's disease, Huntington's disease, Creutzfeldt-Jakob's disease, Parkinson's disease and spinocerebellar degeneration.
REFERENCES:
patent: 3635991 (1972-01-01), Archer
Bolliger et al., Chem. Abstracts 106; 188459r (1987).
Mukai et al., Chem. Abstracts 76: 14367f (1972).
McElvain et al., J. Am. Chem. Soc., vol. 72, pp. 384-389 (1950).
Noring et al., Psychopharmacology (1984) 84:569-571.
Wettstein et al., Psychopharmacology (1984) 84:572-573.
Goto Giichi
Nagaoka Akinobu
Bond Robert T.
Takeda Chemical Industries Ltd.
LandOfFree
Azaspiro compounds and their use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Azaspiro compounds and their use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azaspiro compounds and their use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1365752