Process for preparing carbapenem derivatives

Details Process for preparing carbapenem derivatives Process for preparing carbapenem derivatives

1993-08-02

1994-10-25

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540310, C07D48704, C07D49900

Patent

active

053590597

ABSTRACT:
Process for preparing carbapenem derivative of the formula [I], which comprises subjecting azetidinone compound of the formula [II] to intramolecular cyclization reaction together with elimination reaction of the group of --SR.sup.4, followed by re-adding said group of --SR.sup.4 to the 2-position of the carbapenem skeleton of the intramolecularly cyclized compound, which is industrially useful as process for preparing carbapenem antimicrobials or synthetic intermediate therefor. ##STR1## wherein R.sup.1 is protected or unprotected hydroxy-substituted lower alkyl group, R.sup.2 is hydrogen atom or ester residue, R.sup.3 is hydrogen atom or lower alkyl group, and the group of --SR.sup.4 is group which can be used as substituent at 2-position of the carbapenem antimicrobials.

REFERENCES:
patent: 4194047 (1980-03-01), Christensen et al.

Affiliated with

Also associated with

Rating

Process for preparing carbapenem derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing carbapenem derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing carbapenem derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-136488