Nucleic acid ligands

Details Nucleic acid ligands Nucleic acid ligands

1991-06-10

1995-12-12

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 2104, C07H 2102

Patent

active

054750962

ABSTRACT:
A new class of nucleic acid compounds, referred to as nucleic acid ligands, have been shown to exist that have a specific binding affinity for three dimensional molecular targets. In a preferred embodiment the nucleic acid ligands are identified by the method of the invention referred to as the Systematic Evolution of Ligands by EXponential enrichment (SELEX), wherein a candidate mixture of nucleic acids are iteratively enriched in high affinity nucleic acids and amplified for further partitioning.

REFERENCES:
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patent: 5070010 (1991-12-01), Hus
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Ma et a;. Cell 51:113-119 (Oct. 9, 1987). Maniatis et al. Mol. Cloning-Lab. Man., Cold Spring Harbor, N.Y., 1982, p. 118.
Maniatis et al. Science 236:1237-1245 (Jun. 5, 1987).
Min et al. Muc. Acids Res. 16(11):5075-5088 (1988).
Muesing et al. Nature 313: 450-458 (Feb. 1985).
Oliphant et al. Nuc Acids Res 16(15):7673-7383 (1988).
Romaniuk et al. Biochemistry 26: 1563-1568 (1987).
Watson et al. Mol. Biol. of the Gene, Benjamin/Cummings Publ., Ca. 1987 pp. 267, 295, 323, 361, 394, 396, 397, 405.

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