Antineoplastic heteronapthoquinones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 41, 536 64, 514 25, 514 33, 514 35, A01K 3170, C07H 1524

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active

057365237

ABSTRACT:
This invention relates to a naphthoquinone derivatives, to processes and to intermediates for preparing these derivatives, to pharmaceutical composition and to the use of these derivatives as antitumor agents in mammals.

REFERENCES:
Lo Russo, P. et al. "Antitumor efficacy of PD115934 . . . " Cancer Res., 50, (1990), pp. 4900-4905.
Schabel, F.M. et al. "Establishment of cross-resistance . . . " Cancer Treat. Rep, 67 (1983) pp. 905-922.
Weiss, R.B. et al. "Anthracycline analogs . . . " Cancer Chemother Pharmacol. 18, (1986), pp. 185-197.
Olson, R.D. et al. "Doxorubicin cardiotoxicity . . . " Proc. Natl. Acad. Sci. USA, 85, (1988), pp. 3585-3589.
Mimnaugh, E.G. et al. "Differential oxygen radical . . . " Cancer Research, 49 (1989), pp. 8-15.
McGrath, T. et al. "Multiple mechanisms of adriamycin . . . " Biochemical Pharmacol., 38(3), (1989) pp. 497-501.
Brown, J.R. et al. "5 Recent studies on doxorubicin . . . " Prog. Med. Chem. 21 (1984), pp. 170-236.
Brown, J.R. "3 Adriamycin and related . . . " Prog. Med. Chem., 15, (1978), pp. 125-164.
Moore, H.W. et al. "Naturally occuring quinones . . . " Medicinal Research Reviews, edition J.Wiley & Sons, Inc. vol. 1(3) (1981), pp. 249-280.
Dufat-Trinh Van, H. et al. "Chiral pool synthesis . . . " Heterocycles 26(2), (1987), pp. 341-345.
Dufat-Trinh Van, H. et al. "Total synthesis of 7-hydroxy-. . . " Heterocycles 26(4), (1987), pp. 879-882.
Plumb, J.A. et al. "Effects of the pH dependencies . . . " Cancer Research, 49 (1989), pp. 4435-4440.
Krohn, K. et al. "Konvergente synthese . . . " Liebigs Ann-Chem., (1988), pp. 943-948.
Arcamone, F. "Properties of antitumor anthracyclines . . . " Cancer Research, 45 (1985), pp. 5995-5999.
Acton, E.M. et al. "Intensely potent morpholinyl . . . " J. Med. Chem. 27(5) (1984), pp. 638-645.
Singh, S.B. et al. "Structure and stereochemistry . . . " Tetrahedron Letters 32(36) (1991), pp. 5279-5282.
Alderseley, M.F. et al. "Pyridinium ylides in syntheses . . . " Jour. of Chem. Soc., Perkin Transactions, 1 (1990), pp. 2163-2174.
Hoeksema, H. et al. "Kalafungin II Chemical . . . " Jour. of Antibiotics, 29(7) (1976), pp. 704-709.
Parisot, D. et al. "6-0 dementhyl-5-deoxyfusabarin . . . " Jour. of Antibiotics, 44(1), (1991), pp. 103-107. chem. Soc., Chemical Communications, (1981), pp. 534-535.
Mitsher, L.A. et al. "Total chemical synthesis . . . " J. Med. Chem., 29(1986), pp. 1277-1281.
Chemical Abstracts 94(5)(2 Feb. 1981)#24828t & Euro. J. Pharmacol. 67(1980), pp. 2-3.
Chemical Abstracts 108(21)(23 May 1988),#186527d, & Synthesis 1987(9), pp. 824-827.
Giles, R.G.F. et al. "An investigation into the formation of benzo-. . . " Chem. Soc. Perkin Trans. 1, (1984), p. 2389.
Chemical Abstracts 97(5)(2 Aug. 1982) #38804t & Synth. Commun. 1982, 12(4), pp. 279-285.

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