Novel phosphoric diesters

Details Novel phosphoric diesters Novel phosphoric diesters

1987-03-04

1990-04-03

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 23, 514100, 549220, A61K 31355, C07F 906, C07F 928

Patent

active

049141970

ABSTRACT:
Novel phosphoric diesters of general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each means a methyl group or a hydrogen atom, provided that at least one of R.sub.1 and R.sub.2 is a hydrogen atom, or a salt thereof which can be produced by reacting .beta., .gamma. or .delta.-tocopherol with a halophosphorylating agent such as phosphorus oxychloride, reacting the resultant product with ascorbic acid whereof hydroxyl groups at 5- and 6-positions are protected, and then removing protected groups from the hydroxyl groups. The phosphoric diester has antiinflammatory activity.

REFERENCES:
patent: 4564686 (1986-01-01), Ogata

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