Process for preparing N-acetylneuraminic acid derivatives

Details Process for preparing N-acetylneuraminic acid derivatives Process for preparing N-acetylneuraminic acid derivatives

1984-11-26

1990-04-03

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 553, 536 187, C08B 3700

Patent

active

049141953

ABSTRACT:
A new process for preparing halides of N-acetylneuraminic acids useful as an intermediate in preparing new N-acetylneuraminic acid derivatives having an excellent immunological activity is provided, which process comprises simultaneously acetylating and halogenating an esterified N-acetylneuraminic acid with the aid of an acetyl halide, and according to the process, the halides may be obtained in high yield of about 90%.

REFERENCES:
Kuhn et al., Chem. Ber., 99, 611 (1966).

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