Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1992-10-16
1995-12-12
Henley, III, Raymond J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514625, 514710, 514823, 514922, A61K 4900, A61K 31195, A61K 3116, A61K 3110
Patent
active
054747570
ABSTRACT:
A method of preventing acetaminophen (APAP)-induced hepatotoxicity utilizing diallyl sulfide (DAS) and diallyl sulfone (DASO.sub.2) is disclosed. DAS and DASO.sub.2 are prepared as an oral dosage form or injected. In a preferred embodiment, diallyl sulfone is added to a dosage form of acetaminophen in an amount effective to prevent the metabolism of said unit dose of acetaminophen into its hepatotoxic metabolites. In certain preferred embodiments, the above formulations further include an effective amount of N-acetylcysteine to detoxify hepatotoxic metabolites of acetaminophen.
REFERENCES:
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Brady, et al., "Modulation of Rat Hepatic Microsomal Monooxygenase Enzymes and Cytotoxicity by Dially Sulfide", Toxicol. Appl. Pharm. 108, 342-354 (1991).
Henley III Raymond J.
Rutgers University
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