Process for optical resolution of 1,2-diol derivatives

Details Process for optical resolution of 1,2-diol derivatives Process for optical resolution of 1,2-diol derivatives

1994-11-21

1996-02-20

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

546262, C07C 2700, C07C 2702

Patent

active

054930634

ABSTRACT:
This invention provides a process for producing an optically active 1,2-diol derivative by optical resolution. The optically active 1,2-diol derivative of the formula (I) which is capable of utilizing as an intermediate of fungicidal optically-active azole derivatives can be produced by esterifying a 1,2-diol derivative of the formula (I) as a substrate with a carboxylic acid derivative of the formula (II) as a reagent in the presence of a lipase as a catalyst. ##STR1## wherein R.sup.1 is C1-C5 alkyl group, C3-C7 cycloalkyl group or C1-C5 haloalkyl group, R.sup.2 is C1-C3 alkyl group substituted by a phenyl group which may have one or two halogen atoms and/or C1-C4 alkyl groups, C2-C3 alkenyl group substituted by a phenyl group which may have one or two halogen atoms and/or C1-C4 alkyl groups, or C1-C3 alkyl group substituted by a phenoxy group which may have one or two halogen atoms and/or C1-C4 alkyl groups, R.sup.3 is C1-C10 alkyl group or aryl group, and R.sup.4 is hydrogen atom, C1-C5 alkyl group, C2-C4 alkenyl group or COR.sub.3.

REFERENCES:
patent: 4855438 (1989-08-01), Kaulen et al.
"The Enantiomers of the Azole Fungicide HWG-1608-Asymmetric Synthesis of a 2-Hydroxyethyl Azole Fungicide", Johannes Kaulen, Angew. Chem. Int. Ed. Engl. vol. 28, pp. 462-463, 1989.

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