Processes for producing 2-Halo-nicotinic acid derivatives and pr

Details Processes for producing 2-Halo-nicotinic acid derivatives and pr Processes for producing 2-Halo-nicotinic acid derivatives and pr

1994-01-11

1996-02-20

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21308

Patent

active

054930286

ABSTRACT:
Disclosed are preferred processes for the preparation of 2-halo-nicotinic acid derivatives of formula (IV): ##STR1## by cyclocondensation of a 4-halo-4-cyanocarbonyl compound of formula (III): ##STR2## wherein X is Cl or Br; Y is a carbonyl group and R.sup.1, R.sup.2 and R.sup.3 are each, independently, H, Cl, Br or an organic radical. Further preferred aspects include the preparation of the above-noted 4-halo-4-cyanocarbonyl compound via Michael addition of a 2-halonitrile with an .alpha.,.beta.-unsaturated aldehyde or ketone, and the preparation of the 2-halonitrile by redistribution of halogen between a 2,2-dihalonitrile and a parent nitrile.

REFERENCES:
patent: 4871859 (1989-10-01), Gupton et al.
patent: 5107057 (1992-04-01), Chiang et al.

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