Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-12-08
1994-10-25
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514398, 514399, 514866, 424 49, A61K 31415
Patent
active
053589602
ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging), Accordingly, a composition is disclosed which comprises 2-aminoimidazoles capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation, The method comprises contacting the target protein with the composition, Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
REFERENCES:
patent: 2988478 (1961-06-01), Gordon
patent: 4320134 (1982-03-01), Iizuka et al.
CA80:121003p, Chuiguk et al. (1974).
Bucala et al., Advances in Pharmacology, 23:1-34, Academic Press (1992).
Eble et al., J. Biol. Chem., 258:9406-9412 (1983).
Sell and Monnier, J. Biol. Chem. 264:21597-21602 (1989).
Oimomi et al., Agric Biol. Chem. 53:(6):1767-1728 (1989).
Oimomi et al., Diabetes Research and Clinical Practice, 6:311-313 (1989).
Nicholas et al., Lab. Invest., 60 No. 4, p. 486 (1989).
Brownlee et al., Science, 232:1629-1632 (1986).
Brownlee et al., Diabetes, 35 Suppl. 1, p. 42A (1986).
Nordbo, J. Dent. Res. 58:1429 (1979).
Cerami Anthony
Ulrich Peter
Wagle Dilip R.
Alteon Inc.
Cintins Marianne M.
Jordan Kimberly R.
The Rockefeller University
LandOfFree
Method for inhibiting advanced glycosylation of proteins using a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for inhibiting advanced glycosylation of proteins using a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for inhibiting advanced glycosylation of proteins using a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-135672