Fibrinogen receptor antagonists

Details Fibrinogen receptor antagonists Fibrinogen receptor antagonists

1992-10-14

1994-10-25

Chang, Celia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514305, 514323, 514326, 514538, 546133, 546201, 546208, 546210, 546232, 546233, 546234, 562430, 562439, 562440, 562442, 562454, A61K 31445, C07D21132

Patent

active

053589564

ABSTRACT:
Novel fibrinogen receptor antagonists of the formula: ##STR1## are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.

REFERENCES:
patent: 4064255 (1977-12-01), Champseix et al.
patent: 4122255 (1992-10-01), Krapcho
patent: 4243807 (1981-01-01), Friebe et al.
patent: 4622331 (1986-11-01), Jozic
patent: 5030654 (1991-07-01), Barnish
patent: 5064814 (1991-11-01), Klien et al.
Hartman et al "Nonpeptide fibrinogen receptor autagonist. 1. Discovery and design of exosite inhibitors" J. Med. Chem. 35 4640-4642 (1992).

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