Antipsychotic composition and method of treatment

Details Antipsychotic composition and method of treatment Antipsychotic composition and method of treatment

1992-12-09

1996-02-20

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514211, 514215, 514220, 5142248, 5142255, 5142262, 5142352, 514280, 514341, 514397, 514401, 514402, 514422, 514253, A61K 3154

Patent

active

054929075

ABSTRACT:
A method for treating a serious psychotic mental illness includes the step of administering to a patient in need of such treatment a combination of (i) an .alpha..sub.2 -adrenergic receptor antagonist and (ii) a D.sub.2 dopamine receptor antagonist, A pharmaceutical composition useful in the novel method includes an effective amount of the combination of the foregoing two ingredients together with a pharmaceutically acceptable carrier.

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Doxey et al., "Comparison of the .alpha.-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine," Arch. Pharmacol. 325: 136-44 (1984).
Kane et al., "Clozapine for the Treatment-Resistant Schizophrenic," Arch. Gen. Psychiatry 45: 789-96 (1988).
Litman et al., ".alpha.2 Adrenergic Receptor Antagonist Strategies in the Pharmacology of Schizophrenia," Abstracts of Panels and Posters, Am. Coll. Neuropsychopharmacology, 30th Ann. Mtg. Dec. 9-13, 1991, Poster Session II.

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