Endothelin antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530326, 530324, 530317, 514 9, A61K 3816, C07K 1400

Patent

active

054928923

ABSTRACT:
The present invention as directed to a compound which comprises an endothelin antagonist polypeptide that is at least 40% homologous to an endothelin active peptide, consisting of Et-1, Et-2, Et-3, SC, SA and SB and has the formula: ##STR1## and pharmaceutically acceptable salts.

REFERENCES:
patent: 4981950 (1991-01-01), Masaki et al.
patent: 5114918 (1992-05-01), Ishikawa et al.
Spinella, M. et al., Proc. Natl. Acad. Sci. (USA) 88: 7443-7446 (Aug. 1991).
Gu, Xin et al. Biochem. Biophys. Res. Commun. 179: 130-133, (1991).
Fabregat, I. et al. Journal of Cellular Physiol. 145: 88-94 (1990).
Nakajima, et al., Structure-Activity Relationship of Endothelin: Importance of Charged Groups, Biochemical and Biophysical Research Communications, vol. 163, No. 1, 1989, pp. 424-429.
Topouzis, et al., Effects of calcium entry blockers on contractions evoked by endothelin-1, [Ala.sup.3,11 ]endothelin-1 and [Ala.sup.1,15 ]endothelin-1 rat isolated aorta, Br. J. Pharmacol., 1989, 98, 669-677.
Rovero, et al. Structure-activity studies on endothelin (16-21), the C-terminal hexapeptide of the endothelins, in the guinea-pig bronchus, Br. J. Pharmacol (1990), 101, 232-234.
Spinella, et al., A Proposed Structrual Model of Endothelin, Peptide Research, vol. 2, No. 4 (1989) pp. 286-291.
Randall, et al., Vascular activities of endothelin-1 and same alanyl substituted analogues in resistance beds of the rat, Br. J. Pharmacol, 1989, 98, 685-699.
Maggi, et al., The activity of peptides of the endothelin family in various mammalian smooth muscle preparations, European Journal of Pharmacology, 174, 1989, pp. 23-31.
Kitazumi, et al., Structure-activity relationship in vasocontrictor effects of sarafotoxins and endothelin-1, Febs letters, 1990, vol. 260, No. 2, 269-272.
Hiley, et al, Binding of [.sup.125 I]-endothelin-1 to rat cerebellar homogenates and its reaction with some analogues, Br. J. Pharmacol., 1990, 101, 319-324.
Takasaki, et al., Structure-Receptor Binding Relationships of Sarafotoxin and Endothelin in Procine Cardiovascular Tissue, Biochemistry International, vol. 21, No. 6, Sep. 1990 pp. 1059-1064.
Hirata, et al., Receptor Binding Activity and Cytosolic Free Calcium Response by Synthetic Endothelin Analogs in Cultured Rat Vascular Smooth Muscle Cells, Biochemical and Biophysical Research Communications, vol. 160, No. 1, 1989, pp. 228-234.
Kimura, et al., Structure-Activity Relationships of Endothelin: Importance of the C-Terminal Moiety, Biochemical and Biophysical Research Communications, 1988, vol. 156, No. 3, pp. 1182-1186.
Yanagisawa, et al., Molecular biology and biochemistry of the endothelins, TiPS, Sep. 1989, vol. 10, pp. 374-378.
Moon, et al., Endothelin-like pulmonary vasoconstrictor peptide release by alpha-thrombin, Proc. Natl. Acad. Sci. USA, 1989, 86 pp. 9529-9533.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Endothelin antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Endothelin antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endothelin antagonists will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1355918

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.