Aziridine and phenethanolamine derivatives having antiobesity an

Details Aziridine and phenethanolamine derivatives having antiobesity an Aziridine and phenethanolamine derivatives having antiobesity an

1983-05-09

1987-03-24

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564363, 564365, 544 59, 544 60, 544159, 544160, 544162, 544163, 544146, 544374, 544383, 544399, 544401, 546213, 546232, 546233, 546235, 549 61, 549 65, 549 72, 549 75, 549 76, 549 77, 548954, 548962, 548967, 548768, C07D33338, A61K 3138, A61K 31045, C07C 9106

Patent

active

046526790

ABSTRACT:
Aziridine and phenethanolamine derivatives of formulae I and II-1 ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or lower-alkyl; Z.sup.1 is phenyl or a phenyl group substituted in a defined manner; Z.sup.2 and Z.sup.21 are phenyl or thienyl substituted in a defined manner; and, n is an integer from 1-4. The disclosed compounds have catabolic activity and can be used for the treatment of obesity and/or of sugar illnesses. The compounds of formula I are obtained by dehydrating .beta.-aminoalcohols (e.g. those of formula II-1) which, in turn, can be prepared by adding amines to epoxides or by reducing corresponding iminoketones, iminoalcohols a-keto-.beta.-hydroxyamines or .beta.-ketoamines.

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