Biodegradable implant for fracture nonunions

Details Biodegradable implant for fracture nonunions Biodegradable implant for fracture nonunions

1995-03-13

1996-02-20

Foelak, Morton

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424426, 623 11, A61F 1300

Patent

active

054926971

ABSTRACT:
A biodegradable implant for placement in nonunion bone fractures as a substitute for bone graft material is provided which is a flat plate or disk having a thickness of between about 1 mm and about 15% of the length of the bone, interconnected micropores, and canals substantially equivalent in size and spacing to naturally-occurring Haversian canals. The implant may additionally comprise additives such as growth factors, including bone morphogenic protein. In a preferred embodiment the implant is formed from a biodegradable polymer such as a polylactic acid-polyglycolic acid copolymer by a gel casting technique followed by solvent extraction to precipitate the implant as a microporous solid.

REFERENCES:
patent: 5290494 (1994-03-01), Coombes et al.
patent: 5397572 (1995-03-01), Coombes et al.

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