Benzoylacetate esters as non-sensitizing chelating photo-protect

Details Benzoylacetate esters as non-sensitizing chelating photo-protect Benzoylacetate esters as non-sensitizing chelating photo-protect

1994-03-03

1996-02-20

Chang, Ceila

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

Aromatic acid or derivative containing

514675, 514678, 514680, 514683, 514688, A61K 744

Patent

active

054926904

ABSTRACT:
The subject invention relates to pharmaceutical compositions comprising a safe and effective amount of a compound having the structure: ##STR1## wherein n is 3 or 4; each R is independently alkyl or alkoxy; and R' is C.sub.1 C.sub.20 alkyl; and a pharmaceutically-acceptable topical carrier.
The subject invention also relates to methods for preventing damage to skin, without markedly sensitizing the skin, by topically applying a safe and effective amount of such compounds to the skin.

REFERENCES:
patent: 4911925 (1990-03-01), Shatkina
patent: 5152983 (1992-10-01), Nambudiry
patent: 5292529 (1994-03-01), Gregory
Bhanu et al "Conversion of 4-Phenyl Coremarius into Xanthones" CA 77:1620148 (1972).
Markov et al "On the Photosensitivity of Dibenzoyl Methane" CA 87:134299j (1977).
Patent Abstracts of Japan, vol. 11, No. 53 (C-404) (2500) Feb. 19, 1987: JP A,61 215 318 (Shiseido Co. Ltd.) Sep. 25, 1986.
Donnelly et al. "Structural Modifications of Dalbergin Using Benzeneseleninic Anhydride", Heterocycles, vol. 28, No. 1, pp. 411-419, (1989).
Chemical Abstract Registry No. 101126-46-9 CA 104:133291 (1985).

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