Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-12-11
1994-10-25
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
435226, 530330, A61K 3700, C12N 900
Patent
active
053589343
ABSTRACT:
The subject invention concerns novel peptides which have the property of interfering with the biosynthesis of the enzyme trypsin. This property enables the use of these peptides to, for example, inhibit the formation of progeny in blood-ingesting insects, since trypsin is an essential enzyme for food digestion which provides the essential building blocks for egg development in such insects.
REFERENCES:
patent: 5011909 (1991-04-01), Borovsky et al.
patent: 5130253 (1992-07-01), Borovsky et al.
Borovsky et al Arch. insect Biochem Physiol. vol. 21 (1) 1992 pp. 13-21.
Schwartz, Jean-Charles, Bernard Malfroy, and Sophie De La Baume (1981) "Biological Inactivation of Enkephalins and the Role of Enkephalin-Dipeptidyl-Carboxypeptidase ('Enkephalinase') as Neuropeptidase" Life Sciences 29:1715-1740.
Borovsky, Dov (1985) "Isolation and Characterization of Highly Purified Mosquito Oostatic Hormone" Archives of Insect Biochemistry and Physiology 2:333-349.
Borovsky, Dov. (1988) "Oostatic Hormone Inhibits Biosynthesis of Midgut Proteolytic Enzymes and Egg Development in Mosquitoes" Archives of Insect Biochemistry and Physiology 7:187-210.
Rayne, Richard D., and Michael O'Shea (1992) "Inactivation of Neuropeptide Hormones (AKH I and AKH II) Studied In Vivo and In Vitro" Insect Biochem. Molec. Biol. 22(1):25-34.
Borovsky, Dov, D. A. Carlson, P. R. Griffin, J. Shabanowitz, and D. F. Hunt (1990) "Mosquito oostatic factor: a novel decapeptide modulating trypsin-like enzyme biosynthesis in the midgut" The FASEB Journal 4:3015-3020.
Borovsky, D., C. A. Powell, and D. A. Carlson (1992) "Development of specific ria and elisa to study trypsin modulating oostatic factor in mosquitoes" Arch. Insect Biochem. Physiol. 21(1):13-21.
Borovsky Dov
Carlson David A.
Schmickel D.
The United States of America as represented by the Secretary of
University of Florida
Wax Robert A.
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