Hybrid protein C

Details Hybrid protein C Hybrid protein C

1993-09-23

1994-10-25

Furman, Keith C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530380, 435 696, C07K 1506

Patent

active

053589327

ABSTRACT:
Human protein C molecules are modified to provide increased resistance to inactivation by human plasma factors while retaining substantially the biological activity of human protein C. The modifications are generally to the heavy chain of protein C, which chain may be substituted with a protein C heavy chain of non-human origin, such as bovine, yielding a chimeric protein C molecule. The human protein C heavy chain may also be modified to be human-like, in that at least one amino acid from a non-human sequence may be substituted for the corresponding residue(s) of the human sequence, thereby allowing the molecule to retain substantially human characteristics yet having increased resistance to inactivation. Also included are methods for producing the modified protein C molecules and pharmaceutical compositions thereof. The modified molecules, having an increased half-life in human plasma, are particularly useful for treating coagulation-related disorders, such as protein C deficiency or thrombosis, or for promoting fibrinolysis in a patient.

REFERENCES:
patent: 4775624 (1988-10-01), Bang et al.
patent: 4902614 (1990-02-01), Wakabayashi et al.
patent: 4959318 (1990-09-01), Foster et al.
patent: 4968626 (1990-11-01), Foster et al.
patent: 5077204 (1991-12-01), Brake et al.
patent: 5151268 (1992-09-01), Bang et al.
Suzuki et al., "Characterization of a cDNA for Human Protein C Inhibitor", J. Biol. Chem. 262:611-616 (Jan., 1987).
Heeb et al., "Immunological Identity of Heparin-dependent Plasma & Urinary Protein C Inhibitor & Plasminogen Activator Inhibitor-3", J. Biol. Chem. 262:15813-15816 (Nov., 1987).
Meijers et al., "Inactivation of Human Plasma Kallikrein and Factor XIa by Protein C Inhibitor" Biochem. 27:4231-4237 (1988).
Creighton, T. E. 1978. Prog. Biophys. molec. Biol. 33:231-297.
Foster et al. 1984. Proc. Natl. Acad. Sci. 81:4766-4770.
Wilkinson, J. M. 1986. Practical Protein Chemistry--A Handbook (ed.) A. Darbre, John Wiley & Sons Ltd. pp. 121-148.
Abstract, (DIALOG Accession No. 085287 from file 357) of Patent No. EP 296413, Patent date Dec. 28, 1988.
Brot et al. 1983. Archives of Biochemistry and Biophysics 223(1): 271-281.

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