Process for the production of mixtures of 2-hydroxytetrahydrofur

Details Process for the production of mixtures of 2-hydroxytetrahydrofur Process for the production of mixtures of 2-hydroxytetrahydrofur

1991-05-20

1993-10-19

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

568483, C07D30720, C07C 4559

Patent

active

052547019

ABSTRACT:
Disclosed is a process for the production of an equilibrium mixture of 2-hydroxytetrahydrofuran and 4-hydroxybutanal by a two-step process comprising (1) heating 2,5-dihydrofuran in the presence of a catalyst system comprising a phosphine, ruthenium or rhodium to convert the 2,5-dihydrofuran to 2,3-dihydrofuran; and (2) contacting 2,3-dihydrofuran with water in the presence of an acidic catalyst to convert the 2,3-dihydrofuran to a mixture of 2-hydroxytetrahydrofuran and 4-hydroxybutanal. Also disclosed is a process for the continuous production of an aqueous solution of 2-hydroxytetrahydrofuran and 4-hydroxybutanal. The mixture of 2-hydroxytetra-hydrofuran and 4-hydroxybutanal may be catalytically hydrogenated to produce 1,4-butanediol.

REFERENCES:
patent: 2556325 (1951-06-01), Fluchaire et al.
patent: 4529808 (1985-07-01), Lin et al.
patent: 4533742 (1985-08-01), Lin et al.
patent: 4539415 (1985-09-01), Mueller et al.
patent: 5008408 (1991-04-01), Fischer et al.
Chemical Abstracts, 46:3995f (Mar. 1949).
R. Paul et al., Bull. Soc. Chim. France, pp. 668-671 (1950).
L. Lombardo et al., Aust. J. Chim., 27, pp. 143-152 (1974).
Chemical Abstracts, 91:175179w (1979).
Chemical Abstracts, 91:20308p (Mar. 1979).
A. Polo et al., J. Chem. Soc., Chem. Commun., pp. 600-601 (1990).
K. Hirai et al., Chemical Letters, pp. 23-26 (1982).
Chemical Abstracts, 43:3816, Comp. Rend., 228, 102-104 (1949).
H. A. Bates et al., J. Org. Chem., 50, pp. 3843-3845 (1985).
N. A. Bergman et al., J. Org. Chem., 52, pp. 4449-4450 (1987).
C. D. Hurd et al., J. Am. Chem. Soc., 74, pp. 5324-5326 (1952).

Affiliated with

Also associated with

Rating

Process for the production of mixtures of 2-hydroxytetrahydrofur does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of mixtures of 2-hydroxytetrahydrofur, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of mixtures of 2-hydroxytetrahydrofur will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1352975