Process for producing .alpha.-hydroxyketones

Details Process for producing .alpha.-hydroxyketones Process for producing .alpha.-hydroxyketones

1991-10-18

1993-05-11

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

558311, 558442, 560 53, 560174, 560231, 560266, 560254, 560256, 552542, C07C 4527

Patent

active

052103153

ABSTRACT:
A process for producing an .alpha.-hydroxyketone represented by formula (I): ##STR1## wherein R.sup.1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aralkyl group, or an alkoxycarbonyl group; and R.sup.2 and R.sup.3 each represent a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aralkyl group, provided that they do not simultaneously represent a hydrogen atom; or a pair of R.sup.1 and R.sup.2, a pair of R.sup.1 and R.sup.3, or a pair of R.sup.2 and R.sup.3 is taken together to form a ring; and the pair of R.sup.1 and R.sup.2 and the pair of R.sup.2 and R.sup.3 may form a ring simultaneously, is disclosed, comprising reacting a compound represented by formula (II): ##STR2## wherein R.sup.1, R.sup.2, and R.sup.3 are as defined above, with an oxidizing agent in the presence of a ruthenium compound and water. .alpha.-Hydroxyketones useful as physiologically active substances are produced with good selectivity and in high yield.

REFERENCES:
patent: 3337635 (1967-08-01), Norton et al.
patent: 3518285 (1970-06-01), Fenton et al.
patent: 3879467 (1975-04-01), Zajocek et al.
patent: 4609763 (1986-09-01), Griggs et al.

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