Neristatin 1

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

549267, C07D49322, A61K 31365

Patent

active

051964473

ABSTRACT:
The marine bryozoan Bugula neritina has been found to contain a novel 22-membered macrocyclic lactone which is an inhibitor of lymphocytic leukemia as measured by the US National Cancer Institute's P 388 and in vitro evaluation system. The novel lactone is herein denominated "neristatin 1" and is elucidated.

REFERENCES:
patent: 4560774 (1985-12-01), Pettit et al.
patent: 4611066 (1986-09-01), Pettit et al.
patent: 4833257 (1989-05-01), Pettit et al.

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