Compounds active as inhibitors of the cholesterol biosynthesis

Details Compounds active as inhibitors of the cholesterol biosynthesis Compounds active as inhibitors of the cholesterol biosynthesis

1990-05-04

1993-03-23

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483047, 5483061, 5483101, 546271, 514394, 556437, 556428, C07D48700, C07D40100, A61K 3144, A61K 31415

Patent

active

051964406

ABSTRACT:
The compounds of formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 have the meanings given in the specification, as described.
The compounds of formula I are active as inhibitors of the enzyme HMG-CoA reductase and can be used in therapy as anti-hypercholesterolemics.

REFERENCES:
patent: 4613610 (1986-09-01), Wareing
patent: 4925853 (1990-05-01), Smith et al.

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