Imidazo[4,5-b]qinolinyl oxy alkyl ureas

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142328, 514256, 514293, 544126, 544333, 544361, 546 82, A61K 31495, A61K 31505, A61K 31535, C07D40100

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active

051964287

ABSTRACT:
A novel series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones having enhanced water solubility bioavailability and metabolic stability is disclosed in the Formula I ##STR1## Wherein R is H, or C.sub.1 -C.sub.4 lower alkyl;

REFERENCES:
patent: 3932407 (1976-01-01), Beverung, Jr. et al.
patent: 4256748 (1981-03-01), Chodnekar et al.
patent: 4490371 (1984-12-01), Jones et al.
patent: 4668686 (1987-05-01), Meanwell et al.
patent: 4701459 (1987-10-01), Meanwell et al.
patent: 4775674 (1988-10-01), Meanwell et al.
patent: 4943573 (1990-07-01), Meanwell
S. Seiler, et al., "Imidazoquinoline Derivatives: Potent Inhibitors of Platelet cAMP Phosphodiesterase which Elevate cAMP Levels and Activate Protein Kinase in Platelets," Throm.Res., 62: 31-42 (1991).
Kozak, et al., Bull. Intern. Acad. Polanaise, 1930A: 432-438 (Chem. Abs. 25, 5400).
J. S. Fleming, et al., New Drugs Annual: Cardiovascular Drugs, Raven Press, 277-294, N.Y. (1983).
J. S. Fleming, J. O. Buchanan, S. M. Seiler, and N. A. Meanwell, "Antithrombotic Acticity of BMY 43351, a New Imidazoquinoline with Enhanced Aqueous Solubility," Thromb.Res., 63, 145-155 (1991).
T. Shioiri, K. Ninomiya and S. Yamada, "Diphenylphosphoryl Azide. A New Convient Reagent for a Modified Curtius Reaction for the Peptide Synthesis," J.Amer.Chem.Soc., 94, 6203-6205 (1972).
M.C. Venuti, et al., "Inhibitors of Cyclic AMP Phosphodiesterase. 2. Structural Variations of N-Cyclohexyl-N-Methyl-4-[(1,2,3,5-tetrahydro-2-oxoimidazo-[2,1-b]quinazoli n-7-yl)oxyl]butyramide (RS82856)", J.Med.Chem., 30, 303-318 (1987).

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