Process for forming a fluoromethyl ketone

Details Process for forming a fluoromethyl ketone Process for forming a fluoromethyl ketone

1991-08-14

1993-05-11

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

530330, 530331, 530335, 560 37, 560 51, 560169, 560170, 560174, 560192, 568319, 568355, 568397, C07C31504, C07C 4541

Patent

active

052102726

ABSTRACT:
The preparation of magnesium benzyl fluoromalonate and other equivalent materials, the synthetic equivalents of the --CH.sub.2 F moiety, is described. Reaction between these reagents and the in situ-formed imidazolides of various carboxylic acids gives beta-keto-alpha-fluoroesters, which upon hydrogenation and spontaneous decarboxylation yields fluoromethyl ketones in excellent yields. The overall transformation from RCOOH to RCOCH.sub.2 F is thus illustrated.

REFERENCES:
patent: 4518528 (1985-05-01), Rasnick
Rozen, S. et al., Tetrahedron Letters, 41:1111-1153, (1985).
Brooks, D. W. et al., Angew. Chem. Int. Ed. Eng., 18:72-74, (1979).
Mansour, T. S., Synth. Commun., 19 (Nos. 3 & 4): 659-665, (1989).

Affiliated with

Also associated with

Rating

Process for forming a fluoromethyl ketone does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for forming a fluoromethyl ketone, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for forming a fluoromethyl ketone will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1351679