Preparation for treating and preventing thromboses and thromboem

Details Preparation for treating and preventing thromboses and thromboem Preparation for treating and preventing thromboses and thromboem

1992-02-21

1993-10-19

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 12, 514 24, A61K 3700

Patent

active

052545326

ABSTRACT:
A preparation for the treatment and prevention of thromboses and thromboembolic complications is disclosed, which preparation has a content of protein S at a concentration at least 50 times that present in native plasma and is free from C4b-binding protein, optionally in combination with a content of activated protein C.

REFERENCES:
English language abstract of PCT Patent Application No. WO 8902747 (Apr. 6, 1989).
English language abstract of European Patent Application No. EP 255771 (Feb. 10,1988).
Jenny R. et al., "Purification of six human vitamin K-dependent proteins in a single chromatographic step using immunoaffinity columns." Prep. Biochem. 16(3), 1986, 227-246. [Biological abstract No. 82108551 only].
Litwiller R. D. et al., "Monoclonal antibodies in human vitamin K-dependent protein S." Blood 67(6) 1986, 1583-1590 [Biological abstract No. 82050635 only].
Kohler and Milstein, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature, 256:495-497 (1975).
Schwarz et al., "Plasma Protein S Deficiency in Familial Thrombotic Disease", Blood, 64:1297-1300 (1984).
Griffin et al., "Plasma Protein S Deficiency and Thromboembolic Disease", Progress in Hematology, 15:39-49 (1987).
Laurell, "Electroimmuno Assay", Scand. J. Clin. Lab. Invest., 29:21-37 (1972).
Lowry et al., "Protein Measurement With the Folin Phenol Reagent", J. Biol. Chem., 193:265-275 (1951).
Laemmli, "Cleavage of Structural Proteins During the Assembly of the Head of Bacteriophase T4", Nature, 227:680-685 (1970).
Fareed et al., "A Modified Stasis Thrombosis Model to Study the Antithrombotic Actions of Heparin and its Fractions", In: Seminars in Thrombosis and Hemostasis, II:155-175 (1985).
Wessler et al., "Biological Assay of a Thrombosis-Inducing Activity in Human Serum", J. Appl. Physiol., 14:943-946 (1959).
Comp et al., "Familial Protein S Deficiency is Associated with Recurrent Thrombosis", J. Clin. Invest., 74:2082-2088 (1984).

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