Vectors and compounds for expression of zymogen forms of human p

Details Vectors and compounds for expression of zymogen forms of human p Vectors and compounds for expression of zymogen forms of human p

1991-10-04

1993-03-23

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 435226, 43524025, 4353201, 536 235, 935 14, 935 27, 935 34, 935 48, C12N 964, C12N 1506, C12N 1579, C12N 1552

Patent

active

051963221

ABSTRACT:
A method for the recombinant production of zymogen forms of human protein C is described. These zymogen forms differ from native zymogen protein C in their increased sensitivity to activation by thrombin and thrombin/thrombomodulin. DNA compounds, vectors, and transformants useful in the method are also disclosed.

REFERENCES:
patent: 4775624 (1988-10-01), Bang et al.
Norris et al., Nucleic Acids Research, vol. #15, pp. 5103-5107 (1983).
Chang, J. "Thrombin Specificity," Eur. J. Biochem., 151: 217-224 (1985).
Marsh et al., 1983, Biochemistry 22:4170.
Endres et al., 1975, Arch. Bioch. Biophy. 168:180.
Chang, 1985, Eur. J. Biochem. 151:217.
Fenton, 1981, Ann. N.Y. Acad. Sci. 370:468.

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