Method for the synthesis, compositions and use of 2'-deoxy-5-flu

Details Method for the synthesis, compositions and use of 2'-deoxy-5-flu Method for the synthesis, compositions and use of 2'-deoxy-5-flu

1991-02-22

1993-05-11

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 85, 544317, A61K 31505, C07D41104

Patent

active

052100855

ABSTRACT:
The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds.

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