Thiazole compounds and pharmaceutical composition comprising the

Details Thiazole compounds and pharmaceutical composition comprising the Thiazole compounds and pharmaceutical composition comprising the

1990-03-19

1992-09-08

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548200, 548204, A61K 31425, C07D27724

Patent

active

051458608

ABSTRACT:
The invention relates to new thiazole compounds, of antithrombotic, vasodilating, antiallergic, antiinflammatory and 5-lipoxygenase inhibitory activity, of the formula: ##STR1## wherein A is lower alkylene or carbonyl; R.sup.1 and R.sup.2 are each halogen, lower alkyloxy, lower alkylthio or lower alkylsulfinyl;

REFERENCES:
patent: 4098898 (1978-07-01), Durant
patent: 4166856 (1979-09-01), Durant
patent: 4168315 (1979-09-01), Rynbrandt
Justus Liebigs Annalen Der Chemie, vol. 679, 1964, pp. 144-150, Weinheim, Del T. Pyl et al.: "Uber bicyclische Heterocyclen mit gemeinsamem Stickstoffatom, IX.sup.1 Zur Kenntnis der Imidazo [5.1-b] thiazole" pp. 145,148, compound IIb.

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