Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-04-12
1976-12-14
Mars, Howard T.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260244R, 260256VF, 260295T, 260296T, 260307R, 2603097, 260471R, 424250, 424263, 424272, 424273, C07C14960
Patent
active
039975916
ABSTRACT:
Tricyclic benzodiazepine derivatives (A) bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.
REFERENCES:
patent: 3261867 (1966-07-01), Fryer et al.
patent: 3455985 (1969-07-01), Sternbach et al.
patent: 3504015 (1970-03-01), Archer et al.
patent: 3928415 (1975-12-01), Grove et al.
Derieg Michael Edward
Earley James Valentine
Fryer Rodney Ian
Sternbach Leo Henryk
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Mars Howard T.
Welt Samuel L.
LandOfFree
Tricyclic benzodiazepines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tricyclic benzodiazepines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic benzodiazepines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1344697