Synthesis of cyclic disulfone compounds

Details Synthesis of cyclic disulfone compounds Synthesis of cyclic disulfone compounds

1981-08-19

1982-09-07

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

542441, 549 11, 549 35, C07D33900, C07D33906, C07D33908

Patent

active

043485294

ABSTRACT:
This invention relates to a method of synthesizing bis-sulfones of the formula ##STR1## wherein R.sup.1 and R.sup.2 each are hydrogen, alkyl, phenalkyl, phenyl or phenyl-substituted with an electron-donating or electron-withdrawing group and n is an integer 2, 3 or 4 (a) by reacting a 1,3-dithio compound with n-butyllithium to generate the anion of said compound, (b) reacting said anion with a carbonyl compound to give the 2-substituted carbonol anion intermediate, (c) reacting said intermediate with an acyl chloride or a chloroformate to give the corresponding ester, and (d) reacting said ester with a peracid to give the bis-sulfone product. The subject invention also is concerned with the novel intermediates of step (c).

REFERENCES:
Seebach et al., J. Org. Chem., vol. 40 (1975), pp. 231-237.
Corey et al., Tetra. Lett., vol. 33 (1967), pp. 3201-3204.

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