Process in purification and concentration of the factor VIII-com

Details Process in purification and concentration of the factor VIII-com Process in purification and concentration of the factor VIII-com

1980-12-11

1982-09-07

Marantz, Sidney

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, 424177, A23J 106

Patent

active

043483151

ABSTRACT:
A process in purification and/or concentration of factor VIII complex, starting from a preparation of factor VIII complex, obtained and concentrated in a known manner, mostly in the form of a precipitate, such as cryoprecipitate or Cohn's fraction I-0. This preparation is dissolved in a glycine solution of at least 1.5 M at a temperature of at least +15.degree. C. and pH of 6.3-7.8 and a supernatant liquid is recovered as a product or for further working-up.

REFERENCES:
patent: 3631018 (1971-12-01), Shanbrom
patent: 3652530 (1972-03-01), Johnson
patent: 4081432 (1978-03-01), Delente
patent: 4087415 (1978-05-01), Bick
"Arkiv For Kemi", 12, (1958), 36, T. 387-396, (IAP 395, Second Paragraph).

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