Agglutination tests for detecting influenza viruses, and reagent

Details Agglutination tests for detecting influenza viruses, and reagent Agglutination tests for detecting influenza viruses, and reagent

1980-03-05

1982-10-19

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7, 435 18, 435174, 435810, 23230B, 424 12, C12Q 170, C12Q 134, G01N 3300

Patent

active

043551025

ABSTRACT:
The present invention relates to a new test for detecting influenza viruses. This test comprises: 1- the addition of influenzia virus or of allantoic liquid containing said virus to neuraminidase substrate containing at least one sialic acid group. The substrate is fixed by covalent coupling to an appropriate insoluble solid support, it being understood that said substrate may be formed by all types of mucoproteins, oligosaccharides, mucopolysaccharides or mucolipids comprising at least one sialic acid group capable of being used as a neuraminidase substrate; 2- incubation of the influenza virus with its substrate for an appropriate length of time; 3- then reading the reaction.

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Holmquist, "Preparation of Sepharose-Bound .alpha.-Ketosides of N-Acetylneuraminic Acid and their Interaction with Vibrio cholerae Neuraminidase, Chem. Absts., vol. 82, No. 11, (1975), p. 158, Abs. No. 69667h.
Thraenhart, et al., "Standardization of a Rapid Modified Micro-Neuraminidase-Inhibition Test (Essen-NIT) for Influenza Virus-Neuraminidase Antibody Assay and Comparison with W.H.O. Method", J. Biol. Stand., vol. 4 (1976). pp. 225-241.
Santer, et al., "A Rapid Assay for Neuraminidase", Brochim. Biophys. Acta., vol. 523, (1978), pp. 435-442.
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