Tricyclic-substituted piperidine antihistamines

Details Tricyclic-substituted piperidine antihistamines Tricyclic-substituted piperidine antihistamines

1981-03-16

1982-10-19

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424263, 424274, 424275, 424300, 424321, 546 80, 546 93, 546101, 546111, 546187, 546188, 546202, 546203, 548208, 548529, 549 63, 560 28, 564 84, 564 95, 564 99, A61K 31445, C07D21114

Patent

active

043550363

ABSTRACT:
Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3 or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ##STR4## is a nitrogen containing ring, ##STR5## must be phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is ##STR6## wherein p is 1 or 2 and n is 1 or 2, R.sup.1 is C.sub.1 to C.sub.6 alkyl, R.sup.2 is hydrogen or C.sub.1 to C.sub.6 alkyl, and the dotted line represents an optical double bond, R.sup.2 being absent if the double bond is present, and Y is substituted carboxylate or substituted sulfonyl. Said antihistamines have little or no sedative effects.

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