Tropyl derivatives

Details Tropyl derivatives Tropyl derivatives

1981-11-09

1982-12-28

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424265, 544 43, 546125, 546132, A61K 3146, C07D45102, C07D51314, A61K 3154

Patent

active

043661548

ABSTRACT:
Tropyl derivatives of the formula: ##STR1## in which R.sup.1 is (a) phenyl linked through a direct bond, --O--, ##STR2## (in which m=2 or 3); (b) diphenylmethyl; or (c) 10H-phenothiazin-10-yl; (each of which type may be substituted, or unsubstituted); R.sup.2 is --H, --OH, or --O Si (CH.sub.3).sub.3 ; and R.sup.3 is substituted or unsubstituted phenyl, e.g. 4-[3-(4-fluorobenzoyl)-8-azabicyclo [3.2.1]oct-8-yl]-1-(-4-fluorophenyl)-1-butanone, in free base form or pharmaceutically acceptable acid addition salts are useful as pharmaceuticals.

REFERENCES:
patent: 2800476 (1957-07-01), Stoll et al.
patent: 3987042 (1976-10-01), Gueremy et al.

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