Combined dehydroepiandrosterone and retinoid therapy for epithel

Details Combined dehydroepiandrosterone and retinoid therapy for epithel Combined dehydroepiandrosterone and retinoid therapy for epithel

1992-03-04

2000-07-25

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

A61K 3156

Patent

active

060937068

ABSTRACT:
The present invention relates to compositions and methods for the treatment of oxidative epithelial damage, for inadequate surfactant production in lung disorders, and for disorders of the urinary bladder epithelium. The compositions of the present invention comprise dehydroepiandrosterone and vitamin A derivatives.

REFERENCES:
patent: 4496556 (1985-01-01), Orentreich
patent: 4542129 (1985-09-01), Orentreich
patent: 4628052 (1986-12-01), Peat
patent: 4889847 (1989-12-01), Kligman et al.
William Regelson, M.D., Cancer Investigation, Vitamin A, Dehydroepiandrosterone (DHEA) and 5' Nucleotidase: Regulatory Factors in Tumor Growth, 1985, pp. 407-409.
Feingold, "A Dermatological Viewpoint of the Permeability Barrier," Cosmetics & Toiletries, 107, 41-42 (1992).
Li et al., "Age dependent lipid and protein changes in individual bovine lenses," Current Eye Research, 6, 599-605 (1987).
Regelson et al., "Dehydroepiandrosterone (DHEA): The Precursor Steroid: Introductory Remarks," Dehydroepiandrosterone (DHEA), 1-6 (1990).
Regelson et al., "DHEA: Some Thoughts as to Its Biologic and Clinical Action," Dehydroepiandrosterone (DHEA), 405-445 (1990).

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