Use of dopamine receptor antagonists in palliative tumor therapy

Details Use of dopamine receptor antagonists in palliative tumor therapy Use of dopamine receptor antagonists in palliative tumor therapy

1997-12-05

2000-07-25

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514322, A61K 31685, A61K 31445

Patent

active

060937041

ABSTRACT:
The side effect of decrease in body weight caused by the alkylphosphocholines such as miltefosine can be antagonized by certain acetylcholine receptor antagonists such as domperidone and pimozide. The combination of alkylphosphocholine plus the antagonist does not have any effect on the anti-tumor action of the alkylphosphocholine. The combination also caused no new side effects in the animals.

REFERENCES:
Willis et al., Pharmacol., Biochem. Behav., 31(1), 69-73 Abstract Only, 1988.
Frussa-Filho et al., Braz. J. Med. Biol. Res., 24(6), 611-14 Abstract Only, 1991.
Spruss et al., J. Cancer Res. Clin. Oncol., 119(3), 142-9 Abstract Only, 1993.
"A dose-finding study of miltefosine (hexadecylphosphocholine) in patients with metastatic solid tumours"; Verweij, J., Planting, A., van der Burg, M., Stoter, G.; Department of Medical Oncology, Rotterdam Cancer Institute/Daniel den Hoed Kliniek, The Netherlands; J Cancer Res Clin Oncol 1992; 118(8):606-8. Abstract only.
"Phase II study of daily oral miltefosine (hexadecylphosphocholine) in advanced colorectal cancer"; Planting AS, Stoter, G., Verweij, J.; Department of Medical Oncology, Rotterdam Cancer Institute/Dr. Daniel den Hoed Kliniek, The Netherlands; Eur J. Cancer 1993;29A(4):518-9. Abstract only.
Rote Liste 1998; Arzneimittelverzeichnis des Bundesverbandes der Pharmazeutischen Industrie e.V. (BPI), des Verbandes Forschender Arzneimittelhersteller e.V. (VFA), des Bundesfachverbandes der Arzneimittel-Hersteller e.V. (BAH) und des Verbandes aktiver Pharmaunternehmen e.V. (VAP); ECV, Editio Cantor, Aulendorf/Wurtt. Abstract only.
"Effects of domperidone in patients with chronic unexplained upper gastrointestinal symptoms: a double-blind, placebo-controlled study"; Davis RH, Clench MH, Mathias JR; Department of Medicine, College of Medicine, University of Florida, Gainesville; Dig Dis Sci 1988 Dec; 33(12):1505-11. Abstract only.

Affiliated with

Also associated with

Rating

Use of dopamine receptor antagonists in palliative tumor therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of dopamine receptor antagonists in palliative tumor therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of dopamine receptor antagonists in palliative tumor therapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1336703