Homologs of aprotinin produced from a recombinant host, process

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

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C07R 710

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048944360

ABSTRACT:
Microbially produced aprotinin and aprotinin homologs used for treating patients suffering from an excess release of pancreatic elastase, serum elastase or leukocyte elastase.

REFERENCES:
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Wilcken-Bergmann et al, "A synthetic operon containing 14 bovon pancreatic trypsin inhibitor genes is expressed in E. coli", EMBO Journal, vol. 5, #12, pp. 3219-3225 (1986).
Anderson S., and Kingston, B. I. "Isolation of a genomic clone for bovine pancreatic trypsin inhibitor by using a unique-sequence synthetic DNA probe", Proc. Natl. Acad. Sci., USA, vol. 80, pp. 6838-6842, Nov. 1983 Biochemistry.
Jering et al, "Replacement of lysin by arginine, phenylalanine and tryptophan in the reactive site of the bovine trypsin-k allikrein inhibitor (kunitz) and charge of the inhibitory properties", Chemical Abstracts, vol. 84, p. 229, (1986).
Journal of Cellular Biochemistry, Suppl. 9B, 1985, Abstracts of 14th Annual Mettings, Mar. 9-Apr. 4, 1985, Marks, C. B. et al, "Expression and mutagenesis of bovine pancreatic tyrpsin inhibitor".

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