Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1991-01-25
1992-09-08
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424495, 424499, A61K 914
Patent
active
051456842
ABSTRACT:
Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions containing the particles. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.
REFERENCES:
patent: 2671750 (1954-03-01), Macek
patent: 4107288 (1978-08-01), Oppenheim
patent: 4540602 (1985-09-01), Motoyama
patent: 4826689 (1989-05-01), Violanto
patent: 4851421 (1989-07-01), Iwasaki et al.
Lachman et al., "the Theory and Practice of Industrial Pharmacy", Chapter 2, Milling (1986).
Remington's Pharmaceutical Sciences 17th Edition, Chapter 20, Schott, H., "Colloidal Dispersions".
Bishop John F.
Cundy Kenneth C.
Czekai David A.
Liversidge Gary G.
Benston, Jr. William E.
Davis William J.
Page Thurman K.
Rosenstein Arthur H.
Sterling Drug Inc.
LandOfFree
Surface modified drug nanoparticles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Surface modified drug nanoparticles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Surface modified drug nanoparticles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-133046