Surface modified drug nanoparticles

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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424495, 424499, A61K 914

Patent

active

051456842

ABSTRACT:
Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions containing the particles. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.

REFERENCES:
patent: 2671750 (1954-03-01), Macek
patent: 4107288 (1978-08-01), Oppenheim
patent: 4540602 (1985-09-01), Motoyama
patent: 4826689 (1989-05-01), Violanto
patent: 4851421 (1989-07-01), Iwasaki et al.
Lachman et al., "the Theory and Practice of Industrial Pharmacy", Chapter 2, Milling (1986).
Remington's Pharmaceutical Sciences 17th Edition, Chapter 20, Schott, H., "Colloidal Dispersions".

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